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KMID : 0988920120100030289
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Intestinal Research
2012 Volume.10 No. 3 p.289 ~ p.294
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Recurrent Acute Pericarditis Induced by 5-aminosalicylates in a Patient with Inflammatory Bowel Disease
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Choi A-Ra
Kim Mi-Na
Lee Ji-Hoon
Lee Yong-Kang
Park Yoon-Hye
Shin Hye-Sun
Oh Tak-Geun
Park Hee-Jin
Park Min-Suk
Lim Seung-Taek
Park Su-Jung
Hong Sung-Pil
Kim Tae-Il
Kim Won-Ho
Cheon Jae-Hee
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Abstract
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Inflammatory bowel disease (IBD) is an idiopathic chronic inflammation of the intestines. IBD treatment may require anti-inflammatory agents such as sulfasalazine or 5-aminosalicylate (5-ASA) and immunomodulators to control the symptoms. However, these agents have a variety of common adverse effects such as nausea, vomiting, skin rash, leukopenia, thrombocytopenia, and infections. Moreover, rare side effects such as nephrotic syndrome, pneumonitis, and pericarditis can occur. A 21-year-old male was admitted to the hospital due to acute chest pain, fever, and sweating. The patient had a history of Crohn’s disease and had been taking mesalazine for 3 weeks. Chest x-ray, echocardiography, and clinical manifestations revealed that the patient had acute pericarditis. However, we did not recognize the relationship between these findings and 5-ASA at that time. Two years later, the patient took 5-ASA again, and similar symptoms occurred, which led us to confirm that he suffered from pericarditis induced by this drug. We report a case of acute recurrent pericarditis that developed after taking 5-ASA for IBD treatment with a review of the literature.
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KEYWORD
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Crohn Disease, Colitis, Ulcerative, Mesalamine, Pericarditis
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